Product Description

Serum is the fraction of blood remaining after coagulation and centrifugal of the cellular parts. It provides an extreme complex mixture of plasma proteins, growth factors, hormones etc. that makes it the commonly used supplement in cell culture. Components may vary according to origin, nutritive conditions and processing. Because of these natural variations it is necessary to do batch testing.The high quality of Hexcell – Berlin GmbH sera is based on the careful selection of raw serum, an optimized filtration process and sterile bottling. The aseptic filling of sera results in an aerea of the purity class A with a background environment of the purity class B according to the complementary GMP guidelines for the manufacture of sterile drugs, annex 1.

Growth support level of sera in cell and tissue culture is determined through extensive biological testing, including growth tests with a range of commonly used cell lines. All sera have to test negative for mycoplasma. The release of the sera is only effected after a negative result.

Fetal Bovine Serum (FBS) and Newborn Calf Serum are examined to exclude viruses such as Bovine Virus Diarrhoea (BVD-MD), Bovine Herpes Virus type 1 (BHV*1), and Parainfluenza Virus type 3 (PI*3). Test results have to prove negative with respect to cytopathogenicity and immunperoxidase staining. FBS is screened also for antibodies against these virus types.